The "JD Vance is weird" is cringe and obviously disingenuous. The lefties pushing that meme don't care if someone is weird, as they are full of freaks. They are hoping that those on the right do care though.
After people already voted for Trump in spite of all the factors with him, I doubt this will make a difference with Vance. I consider Vance a non-factor in the overall election anyways, like many vice-presidents.