@judgedread @okayyeahwhatever The two most prominent examples in Orthodoxy of people who suffer from spiritual and biological diseases that turn them into Enemies of Humanity are the jews themselves and people possessed by demons (there is a lot of overlap). For the jews this sickness is now clearly genetic: "His blood be on us and on our children."
Those natural Enemies of Humanity who do not resist their corrupt nature should be delivered to the Most High Judge swiftly and efficiently by Imperial military and police forces. The tough issue is what to do with those jews and demoniacs who recognize their diseased nature but who sincerely want their nature to be changed so they are no longer a threat. Without advanced genetic engineering or Divine Intervention this is likely impossible -- Orthodox Christians should aggressively pursue both avenues.
Ideally we would contain these unfortunates with the same aggressiveness we would (other) vampires or zombies while we worked and prayed for a treatment. The Church would administer sacraments to them while in containment, but allowing them to participate in Church leadership would obviously be extremely foolish.
The key Christian principle at work here is aggressively protecting the population from the threat these biological enemies pose without judging their spiritual condition. They didn't choose to be biological parasites: we do not expect God to judge them spiritually for their sickness so neither should we.
@TrevorGoodchild